Volume 71 of Advances in Cancer Research begins with Morgan and Kastan presenting data on the roles of p53 and
ATM in cell cycle progression and cell death in response to DNA damage and how this information may lead to targets
for improved cancer therapies. Kok et all. Review the methodological advantages and limitations to localizing tumor
suppressor genes, especially those on the short arm of chromosome 3. Peltomaki and de la Chapelle describe research
on mismatch repair genes and their effects on colorectal cancer. McKenna and Cotter present findings on the functions
and failures of apoptosis in the hematopoietic system. Ravitz and Wenner review TGF-B and how it controls and affects
cell cycle progression in a variety of cell types. Andrew Simpson presents data on the mutation frequencies of
microsatellites in human carcinogenesis. Naor and colleagues present research on a multitude of tumors expressing
levels of CD44 and discuss how CD44 may be used as a target for cancer therapy. Luisa Villa discusses various aspects
of HPV and the potential clinical use of HPV testing in cervical cancer prevention programs. Last, Disis and Cheever
review the studies that define HER-2/neu specific immunity in patients with cancer and the current vaccine strategies
for generating specific immunity.