The updated 2nd edition of this accessible and in-depth resource firmly relates molecular and cellular biology to the study of human physiology and disease. Leading physiologists present you with practical, accurate coverage, continually emphasizing the clinical implications of the material. Each chapter explains the principles and organization of each body system, while more than 800 high-quality, full-color line drawings and prominently featured clinical examples clarify every concept. This exceptionally detailed and comprehensive guide to physiology is ideal for a rich, straightforward, state-of-the-art understanding of this essential subject. Provides clinical examples of disordered physiology in prominent boxes throughout the text for at-a-glance access to important content. Clarifies concepts with the use of 800 color drawings that feature balloon captions explaining key processes. Presents material in a consistent style to make the text readable and easy to understand. Offers a practical organization by body system for an intuitive and accessible approach to physiology. Features access to the complete contents of the book online, plus a full image collection, animations, 150 review questions, and supplemental web notes for more detailed information. Keeps you current with updated material, including a new chapter on Physiology of Aging and a new section on hemostasis. Offers the latest visual guidance with a revised and updated art program. Your purchase entitles you to access the web site until the next edition is published, or until the current edition is no longer offered for sale by Elsevier, whichever occurs first. If the next edition is published less than one year after your purchase, you will be entitled to online access for one year from your date of purchase. Elsevier reserves the right to offer a suitable replacement product (such as a downloadable or CD-ROM-based electronic version) should online access to the web site be discontinued.

I Introduction
Chapter 1 Foundations of Physiology, Emile L. Boulpaep and Walter F. Boron

II Physiology of Cells and Molecules
Chapter 2 Functional Organization of the Cell, Michael J. Caplan
Chapter 3 Signal Transduction, Lloyd Cantley and Laura M. Roman
Chapter 4 Regulation of Gene Expression, Peter Igarashi
Chapter 5 Transport of Solutes and Water, Peter S. Aronson, Walter F. Boron, and Emile L. Boulpaep
Chapter 6 Electrophysiology of the Cell Membrane, Edward G. Moczydlowski
Chapter 7 Electrical Excitability and Action Potentials, Edward G. Moczydlowski
Chapter 8 Synaptic Transmission and the Neuromuscular Junction, Edward G. Moczydlowski
Chapter 9 Cellular Physiology of Skeletal, Cardiac, and Smooth Muscle, Edward G. Moczydlowski and Michael Apkon

III The Nervous System
Chapter 10 Organization of the Nervous System, Bruce R. Ransom
Chapter 11 The Neuronal Microenvironment, Bruce R. Ransom
Chapter 12 Physiology of Neurons, Barry W. Connors
Chapter 13 Synaptic Transmission in the Nervous System, Barry W. Connors
Chapter 14 The Autonomic Nervous System, George B. Richerson
Chapter 15 Sensory Transduction, Barry W. Connors
Chapter 16 Circuits of the Central Nervous System, Barry W. Connors

IV The Cardiovascular System
Chapter 17 Organization of the Cardiovascular System, Emile L. Boulpaep
Chapter 18 Blood, Emile L. Boulpaep
Chapter 19 Arteries and Veins, Emile L. Boulpaep
Chapter 20 The Microcirculation, Emile L. Boulpaep
Chapter 21 Cardiac Electrophysiology and the Electrocardiogram, W. Jonathan Lederer
Chapter 22 The Heart As a Pump, Emile L. Boulpaep
Chapter 23 Regulation of Arterial Pressure and Cardiac Output, Emile L. Boulpaep
Chapter 24 Special Circulations, Steven S. Segal
Chapter 25 Integrated Control of the Cardiovascular System, Emile L. Boulpaep

V The Respiratory System
Chapter 26 Organization of the Respiratory System, Walter F. Boron
Chapter 27 Mechanics of Ventilation, Walter F. Boron
Chapter 28 Acid-Base Physiology, Walter F. Boron
Chapter 29 Transport of Oxygen and Carbon Dioxide In the Blood, Walter F. Boron
Chapter 30 Gas Exchange in the Lung, Walter F. Boron
Chapter 31 Ventilation and Perfusion of the Lungs, Walter F. Boron
Chapter 32 Control of Ventilation, George B. Richerson and Walter F. Boron

VI The Urinary System
Chapter 33 Organization of the Urinary System, Gerhard Giebisch and Erich Windhager
Chapter 34 Glomerular Filtration and Renal Blood Flow, Gerhard Giebisch and Erich Windhager
Chapter 35 Transport of Sodium and Chloride, Gerhard Giebisch and Erich Windhager
Chapter 36 Transport of Urea, Glucose, Phosphate, Calcium, Magnesium, and Organic Solutes, Gerhard Giebisch and Erich Windhager
Chapter 37 Transport of Potassium, Gerhard Giebisch and Erich Windhager
Chapter 38 Urine Concentration and Dilution, Gerhard Giebisch and Erich Windhager
Chapter 39 Transport of Acids and Bases, Gerhard Giebisch and Erich Windhager
Chapter 40 Integration of Salt and Water Balance, Gerhard Giebisch and Erich Windhager

VII The Gastrointestinal System
Chapter 41 Organization of the Gastrointestinal System, Henry J. Binder
Chapter 42 Gastric Function, Henry J. Binder
Chapter 43 Pancreatic and Salivary Glands, Christopher R. Marino and Fred S. Gorelick
Chapter 44 Intestinal Fluid and Electrolyte Movement, Henry J. Binder
Chapter 45 Nutrient Digestion and Absorption, Henry J. Binder and Adrian Reuben
Chapter 46 Hepatobiliary Function, rederick J. Suchy

VIII The Endocrine System
Chapter 47 Organization of Endocrine Control, Eugene J. Barrett
Chapter 48 Endocrine Regulation of Growth and