Griffiths, Anthony J.F. : University of British Columbia

Gelbart, William M. : Harvard University

Lewontin, Richard C. : Harvard University

Miller, Jeffrey H. : University of California, Los Angeles

"The opening example really brings students into the chapters. The example of Huntington's in chapter five is maintained throughout the text as a paradigm, and it really ties this chapter together�In chapter seven, the issue of antibiotic resistance in bacteria is widely known, and tying up the opening discussion at the end of the chapter is an excellent way to bring the chapter full circle. These really give the students a sense of the unified nature of the topics� it all fits together."

--Pat Callie, Eastern Kentucky University

"The opening example is catchy! Most of my students are pre-med, so they will enjoy medical examples."

--Dorothy B. Engle, Xavier University

"�there are so many possibilities with all the genomes online�"

--Jocelyn E. Krebs, University of Alaska

"The summary figures are wonderful! Now I will have a literal �big picture' to show the students for every chapter."

--Vaghn M. Gehle, Southwest State University

W.H. Freeman Web Site, April, 2002

Modern Genetic Analysis 2/e, the second introductory genetics textbook W.H. Freeman has published by the Griffiths author team, implements an innovative approach to teaching genetics. Rather than presenting material in historical order, MGA 2/e integrates molecular genetics with classical genetics. The integrated approach provides students with a concrete foundation in molecules, while simultaneously building an understanding of the more abstract elements of transmission genetics. MGA 2/e also incorporates greater attention to pedagogy, improved chapter organization, enhanced art, and a better overall design, making it a more effective learning tool.

NEW! Chapters are now grouped into four parts that reflect the broad divisions of modern genetics.

Part 1. Fundamentals of Gene Structure, Function, and Transmission
The core principles of inheritance presented and integrated at the classical and molecular levels. Gene interaction (Chapter 6 in the first edition) now revised and relocated as Chapter 14 in Part 3 to group it with other examples of complex interactions in genetic systems.
1. Genetics and the Organism
2. The Structure of Genes and Genomes
3. Gene Function
4. The Transmission of DNA at Cell Division

DNA replication now enhanced by new figures and consolidated to include mechanism of telomere synthesis (relocated from Chapter 12 in the first edition).
Expanded coverage of prokaryotic DNA replication--now includes rolling circle model.

5. The Inheritance of Single-Gene Differences

Gene inheritance (Chapter 4 in the first edition) now reorganized into two chapters--the molecular and cellular basis of gene inheritance presented in Chapter 4 of this edition provides a basis for understanding the genetic ratios arising in the progeny of heterozygotes discussed in this chapter.

6. Genetic Recombination in Eukaryotes
7. Recombination in Bacteria and Their Viruses

Part 2. Methods of Genetic Manipulation
Genetic engineering and genomics now relocated before mutations to provide background for discussion of the newer techniques of mutation research--site-directed mutagenesis and targeted gene knockouts.
Transposable genetic elements (Chapter 13 in the first edition) now subdivided into topics placed in context as sections of two chapters-- in the genomics chapter their presence as repetitive sequences of eukaryotic genomes; in the gene mutation chapter their mechanisms of transposition and their mutagenic potential.
8. Recombinant DNA and Genetic Engineering

Genetic engineering and its applications (Chapters 10 and 11 in the first edition) now streamlined and reworked into one chapter--a principles-based approach to genetic engineering structured on the common themes of complementarity of nucleic acid sequences and specificity of protein�nucleic acid interactions.

9. Genomics

Updated and revised to present the latest approaches, including a section on functional genomics embracing proteomics and bioinformatics. Sets the stage for an integration of genomic approaches in subsequent chapters, reflecting the fact that genetics and genomics have now become companion disciplines.

10. Gene Mutation: Origins and Repair Processes

Gene mutations (Chapter 7 in the first edition) now expanded into two chapters--this chapter on mechanisms of gene mutation and repair, and a new chapter (Chapter 12) on mutational dissection with a focus on the analytical process.

11. Chromosome Mutations
*12. Mutational Dissection

The power of mutation to manipulate and analyze genetic systems.

Part 3. Systems Genetics: From Gene to Phenotype
The systems of complex interacting genetic components found in living cells.
13. Regulation of Gene Transcription
14. From Gene to Phenotype

An exploration of the complex relationships between genes and environment in controlling phenotype--includes the material on gene interaction from Chapter 6 of the first edition.

15. Regulation of Cell Number: Normal and Cancer Cells
16. The Genetic Basis of Development

Part 4. Genetic Analysis of Populations
The special approaches used to analyze genes at the population level. Evolution (included with population genetics in Chapter 17 of the first edition) now expanded into a separate new chapter.
17. Population Genetics
18. Quantitative Genetics
*19. Evolutionary Genetics

Includes discussion of comparative genomics and proteomics.