O. David Sparkman is Adjunct Professor of Chemistry at the College of the Pacific at the University of the Pacific in Stockton, California.

"This introductory reference book on organic and biological mass spectrometry, with over 3,000 literature citations, most of which are from the last few years, will serve as a textbook for a course on mass spectrometry. Rather than reporting empirical specifications, this book facilitates an understanding of the operating principles of instrumentation and techniques including those for emerging technologies like the orbitrap, ETD, ion mobility spectrometry, and new vacuum systems." "Revised and updated, the text provides a guide to a variety of concepts in mass spectrometry. Many of the illustrative 'real life' examples demonstrate potential qualitative and quantitative applications and limitations of the technology." "Unlike most other mass spectrometry texts, this reference covers both classical and modern mass spectrometry with an emphasis on strategies for data interpretation, fundamental operating principles of instrumentation, and representative applications in many areas of organic, environmental, and biomedical endeavor. The book provides coverage of inlet systems, vacuum systems, detectors, data systems, and specialized techniques such as MS/MS, data-dependent instrument operation, selected ion monitoring, selected reaction monitoring, and automated library searching. In addition to being an introductory text for all students of mass spectrometry, it is also relevant to anyone working with mass spectrometry in such application areas as pharmaceutical, biological, medical, food and environmental research, as well as analytical service providers and regulatory agencies."--BOOK JACKET.

Chapter 1 Introduction I. What is Mass Spectrometry II. History III. Applications IV. The Data of Mass Spectrometry and Its Presentation 1. Spectra 2. Total Ion Current 3. Mass Chromatograms and Profiles V. Definition of Terms 1. Mass-To-Charge Ratio (m/z) 2. Multiple-Charge Ions 3. Ions Representing an Intact Molecule 4. Resolution/Resolving Power 5. Intensity vs Abundance

Chapter 2 The Mass Spectrometer I. Introduction II. Ion Guides III. Types of m/z Analyzers 1. Time-Of-Flight A. Linear 1) Resolving Power of the Linear TOF Instrument 2) Time-Lag Focusing 3) Beam Deflection B. Reflectron C. Orthogonal Acceleration D. Ion Detection in the TOF Analyzer 1) Time Slice Detection 2) Time Array Detection 3) TAD with Transient Recorders 4) TAD with an Integrating Transient Recorder 5) Hadamard Transform TOF MS 2. Quadrupole Ion Traps A. 3D Quadrupole Ion Traps B. Linear Quadrupole Ion Traps 3. Orbitrap A. Historical Aspects B. Operating Principles 4. Transmission Quadrupoles A. QMF Equations of Motion B. The Stability Diagram C. Characteristics of Output D. Spectral Skewing E. Performance Limitations 5. Sector instruments A. Single-focusing Instruments 1) Operating Principles 2) Performance Limitations B. Double-Focusing Instruments 6. FTICR-MS C. Hardware Configuration D. Operational Considerations E. Representative Applications IV. Calibration of the m/z Scale 1. Electron Ionizaton (GC/MS) 2. Chemical Ionization (GC/MS) 3. Electrospray and Other Atmospheric Pressure Ionization Techniques V. Ion Detection 1. General Considerations 2. Types of Detectors A. Faraday Cup B. Electron Multiplier 1) Discrete-Dynode Version 2) Continuous-Dynode Version C. Negative-Ion Detection D. Post-Acceleration Detection and Detection of High-Mass Ions E. Channel Electron Multiplier Array (CEMA) F. Electro-Optical Ion Detection G. The Daly Detector H. Cryogenic Detectors VI. Vacuum Systems 1. Introduction 2. Definitions 3. Pressure Gauges A. Thermal-Conductivity Gauges B. Ionization Gauges 4. Types of Pumps A. Mechanical Pumps (Low Vacuum) 1) Rotary Vane 2) Scroll 3) Diaphram B. High Vacuum 1) Turbomolecular Pumps 2) Diffusion Pumps 3) Sputter-Ion Pumps 4) Cryogenic Pumps

Chapter 3 Mass Spectrometry/Mass Spectrometry I. Introduction 1. Concept and Definitions 2. Nomenclature II. Ion Dissociation 1. Metastable Ions III. Instrumentation for MS/MS 1. MS/MS in Space A. Tandem MS/MS 1) Triple-Quadrupole Mass Spectrometer 2) BEqQ Hybrid Instrument B. Double-Focusing Instruments 2. MS/MS in Time IV. Spe