Written by a pioneer of the use of bioinformatics in research, the second edition of Introduction to Bioinformatics introduces the student to the power of bioinformatics as a set of scientific tools. Retaining and enhancing the rich pedagogy and lucid presentation of the first edition, this new edition explains how to access the data archives of genomes and proteins, and the kind of questions these data and tools can answer. It also discusses how to make inferences from the data archives, how to make connections among them, and how to derive useful and interesting predictions. The book is accompanied by a fully integrated companion website.